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Gene Expression Literature Summary
Assay
Age
Immunohistochemistry (section)
Postnatal

23 matching records from 23 references.

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Myh4  myosin, heavy polypeptide 4, skeletal muscle   (Synonyms: MHC2B, Minimsc, Minmus, MM, MYH-2B, MyHC-IIb, Myhsf)
Results  Reference
1J:322002 Dos Santos M, Backer S, Aurade F, Wong MM, Wurmser M, Pierre R, Langa F, Do Cruzeiro M, Schmitt A, Concordet JP, Sotiropoulos A, Jeffrey Dilworth F, Noordermeer D, Relaix F, Sakakibara I, Maire P, A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes. Nat Commun. 2022 Feb 24;13(1):1039
1J:345130 Eguchi T, Tezuka T, Watanabe Y, Inoue-Yamauchi A, Sagara H, Ozawa M, Yamanashi Y, Calcium-binding protein 7 expressed in muscle negatively regulates age-related degeneration of neuromuscular junctions in mice. iScience. 2024 Feb 16;27(2):108997
1J:227271 Gao YQ, Chen X, Wang P, Lu L, Zhao W, Chen C, Chen CP, Tao T, Sun J, Zheng YY, Du J, Li CJ, Gan ZJ, Gao X, Chen HQ, Zhu MS, Regulation of DLK1 by the maternally expressed miR-379/miR-544 cluster may underlie callipyge polar overdominance inheritance. Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13627-32
1*J:302851 Greschik H, Duteil D, Messaddeq N, Willmann D, Arrigoni L, Sum M, Jung M, Metzger D, Manke T, Gunther T, Schule R, The histone code reader Spin1 controls skeletal muscle development. Cell Death Dis. 2017 Nov 23;8(11):e3173
1J:108465 Issa LL, Palmer SJ, Guven KL, Santucci N, Hodgson VR, Popovic K, Joya JE, Hardeman EC, MusTRD can regulate postnatal fiber-specific expression. Dev Biol. 2006 May 1;293(1):104-15
1J:345111 Jacobson KR, Saleh AM, Lipp SN, Tian C, Watson AR, Luetkemeyer CM, Ocken AR, Spencer SL, Kinzer-Ursem TL, Calve S, Extracellular matrix protein composition dynamically changes during murine forelimb development. iScience. 2024 Feb 16;27(2):108838
1J:277814 Kepser LJ, Damar F, De Cicco T, Chaponnier C, Proszynski TJ, Pagenstecher A, Rust MB, CAP2 deficiency delays myofibril actin cytoskeleton differentiation and disturbs skeletal muscle architecture and function. Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8397-8402
1J:224980 Lee KY, Singh MK, Ussar S, Wetzel P, Hirshman MF, Goodyear LJ, Kispert A, Kahn CR, Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism. Nat Commun. 2015;6:8054
1J:201148 Lee YS, Lee SJ, Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):E3713-22
1*J:268425 Li Z, Parlakian A, Coletti D, Alonso-Martin S, Hourde C, Joanne P, Gao-Li J, Blanc J, Ferry A, Paulin D, Xue Z, Agbulut O, Synemin acts as a regulator of signalling molecules during skeletal muscle hypertrophy. J Cell Sci. 2014 Nov 1;127(Pt 21):4589-601
1J:317555 Liu KX, Edwards B, Lee S, Finelli MJ, Davies B, Davies KE, Oliver PL, Neuron-specific antioxidant OXR1 extends survival of a mouse model of amyotrophic lateral sclerosis. Brain. 2015 May;138(Pt 5):1167-81
1J:58904 Lu BD, Allen DL, Leinwand LA, Lyons GE, Spatial and temporal changes in myosin heavy chain gene expression in skeletal muscle development. Dev Biol. 1999 Dec 1;216(1):312-26
1J:125838 Merrick D, Ting T, Stadler LK, Smith J, A role for Insulin-like growth factor 2 in specification of the fast skeletal muscle fibre. BMC Dev Biol. 2007;7:65
1J:162164 Otto A, Macharia R, Matsakas A, Valasek P, Mankoo BS, Patel K, A hypoplastic model of skeletal muscle development displaying reduced foetal myoblast cell numbers, increased oxidative myofibres and improved specific tension capacity. Dev Biol. 2010 Jul 1;343(1-2):51-62
1J:69803 Palmer S, Groves N, Schindeler A, Yeoh T, Biben C, Wang CC, Sparrow DB, Barnett L, Jenkins NA, Copeland NG, Koentgen F, Mohun T, Harvey RP, The small muscle-specific protein Csl modifies cell shape and promotes myocyte fusion in an insulin-like growth factor 1-dependent manner. J Cell Biol. 2001 May 28;153(5):985-98
1*J:304043 Parente A, Boukredine A, Baraige F, Duprat N, Gondran-Tellier V, Magnol L, Blanquet V, GASP-2 overexpressing mice exhibit a hypermuscular phenotype with contrasting molecular effects compared to GASP-1 transgenics. FASEB J. 2020 Mar;34(3):4026-4040
1J:305082 Pathak P, Blech-Hermoni Y, Subedi K, Mpamugo J, Obeng-Nyarko C, Ohman R, Molloy I, Kates M, Hale J, Stauffer S, Sharan SK, Mankodi A, Myopathy associated LDB3 mutation causes Z-disc disassembly and protein aggregation through PKCalpha and TSC2-mTOR downregulation. Commun Biol. 2021 Mar 19;4(1):355
1*J:267665 Rubio-Solsona E, Marti S, Vilchez JJ, Palau F, Hoenicka J, ANKK1 is found in myogenic precursors and muscle fibers subtypes with glycolytic metabolism. PLoS One. 2018;13(5):e0197254
1J:226889 Sakakibara I, Santolini M, Ferry A, Hakim V, Maire P, Six homeoproteins and a Iinc-RNA at the fast MYH locus lock fast myofiber terminal phenotype. PLoS Genet. 2014;10(5):e1004386
1J:230727 Stark DA, Coffey NJ, Pancoast HR, Arnold LL, Walker JP, Vallee J, Robitaille R, Garcia ML, Cornelison DD, Ephrin-A3 promotes and maintains slow muscle fiber identity during postnatal development and reinnervation. J Cell Biol. 2015 Dec 7;211(5):1077-91
1*J:270838 Wiederstein JL, Nolte H, Gunther S, Piller T, Baraldo M, Kostin S, Bloch W, Schindler N, Sandri M, Blaauw B, Braun T, Holper S, Kruger M, Skeletal Muscle-Specific Methyltransferase METTL21C Trimethylates p97 and Regulates Autophagy-Associated Protein Breakdown. Cell Rep. 2018 May 1;23(5):1342-1356
1J:306954 Zecchini S, Giovarelli M, Perrotta C, Morisi F, Touvier T, Di Renzo I, Moscheni C, Bassi MT, Cervia D, Sandri M, Clementi E, De Palma C, Autophagy controls neonatal myogenesis by regulating the GH-IGF1 system through a NFE2L2- and DDIT3-mediated mechanism. Autophagy. 2019 Jan;15(1):58-77
1J:26105 Zhang W, Behringer RR, Olson EN, Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib anomalies. Genes Dev. 1995 Jun 1;9(11):1388-99

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory